Difference between revisions of "Matching Phenotypes"
From phenoscape
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This page discusses the method developed and implemented in late 2010 for search for, and scoring, phenotype matches between taxa (Phenoscape) and zebrafish mutants (ZFIN). | This page discusses the method developed and implemented in late 2010 for search for, and scoring, phenotype matches between taxa (Phenoscape) and zebrafish mutants (ZFIN). | ||
= Purpose = | = Purpose = | ||
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| + | An important goal for the Phenoscape project is to be able to suggest candidate genes that may have contributed to evolutionary change. The way that we have proposed to do this is to search for changes in phenotype that appear as the result of mutations in model organisms and also appear as phenotype changes on an evolutionary tree. | ||
= Selecting Phenotypes from Taxon Annotations = | = Selecting Phenotypes from Taxon Annotations = | ||
Revision as of 13:32, 4 January 2011
This page discusses the method developed and implemented in late 2010 for search for, and scoring, phenotype matches between taxa (Phenoscape) and zebrafish mutants (ZFIN).
Contents
Purpose
An important goal for the Phenoscape project is to be able to suggest candidate genes that may have contributed to evolutionary change. The way that we have proposed to do this is to search for changes in phenotype that appear as the result of mutations in model organisms and also appear as phenotype changes on an evolutionary tree.
Selecting Phenotypes from Taxon Annotations
Using attributes to limit the scope of quality comparisons
Each phenotype is linked to multiple entities via inheres_in_part_of relations.
Scoring matches of individual phenotypes
Scoring matches of sets of phenotypes (phenotypic profiles) associated with a gene or taxon node
- maxIC
- ICCS
- simIC
- simJ
