Ontology Data Service API
This is a legacy high-level specification of a common programmatic API needed by EQ editors (such as Phenex and Phenote) to interface with ontology (and phenotype) repositories. It resulted from a breakout group, consisting of C. Mungall, J. Balhoff, and H. Lapp, of the Fish Evolution Working Group at their last meeting in November 2006, and served as part of the early input to the web-service design of the Bioportal.
This specification as such has not been implemented in the Phenoscape Knowledgebase (KB), though some functions proposed here are among the implemented Data Services (for example "Look up term" as Term Info and "Completion list" as Autocomplete. Also, the Bioportal meanwhile has a full-featured REST API that does implement all of the ontology-specific functions enumerated below, and the Phenoscape KB Data Services implement a much richer set of phenotype annotation services than envisioned below (albeit read-only).
Goal and motivation
A common API implemented by ontology data services enables clients such as EQ editors that heavily rely on such a service to plug into different data providers, local or remote, at their choice.
Ontology Data Service
- Ontology listing lookup
- Function: lookup the ontologies being served by the data service
- Input: none, or a particular name, and/or the name of the ontology category
- Output: a record of name, version, identifier, meta-data (e.g., retired? in production? purpose?) for each ontology being served
- Look up term
- Function: Obtain the full term information for a given ID
- Input: a term ID, or the combination of a term name and ontology ID
- Output: the matching term in OBO or RDF/OWL format
- Notes: do we need neighborhood here too (e.g., with IDs only); OBO only has parents, not children.
- Completion list
- Function: Obtain matching term names for a partial term name string
- Input: partial term name string, a list of ontology IDs, search parameters (search names only or synonyms only or both, search obsoletes or not, search definition or not)
- Output: matches as records of term name, term ID, ontology ID, synonym that was hit, how the term was hit (name, synonym, or definition)
- Neighborhood graph
- Function: Obtain parents, children, descendants, or ancestors for a given term
- Input: term ID, list of relationships to include or exclude, number of levels (path length) up and down to include
- Output: list of terms in OBO or RDF format
- Note: Is it sensible to return a graph as OBO format? Do we need to mandate the semantics of matching mixed-type paths (e.g., is-a and part-of)?
- Downloading ontology
- Function: Obtain all terms and relationships comprising an ontology
- Input: ontology ID, optionally name of the slim
- Output: the ontology as an OBO or OWL stream of text
- Notes: do we need a parameter for specifying the desired format? do we need parameter for including obsoletes or not
- SPARQL endpoint
- Function: Issue SPARQL queries and obtain the results in RDF
Notes applicable to all:
- Do we need to add search parameter to specify the 'slim' for each service that involves specifying an ontoloy?
- Should we have a protocol for client and server negotiating the desired return format, or should this be a parameter (in which case we also need a method to obtain all supported formats from the server)?
Phenotype Data Service
- Function: Given a username and secret, obtain an authentication token
- Save EQ statements
- Function: Save an array of EQ statements to the data store
- Input: a list of EQ statements on OBD-xml or pheno-xml format
- Output: success/failure indicator
- Load EQ statements
- Function: Load an array of EQ statements from the data store
- Input: author, or list of taxa,
- Output: matching EQ statements in pheno-xml or pheno-syntax format
- Notes: do we need parameter of list of entities to obtain EQs for?
Data exchange formats
- Plain text over HTTP:
- OBO format
- XML over HTTP:
- OBO-XML format
- OBD-XML format
- RDF over HTTP:
Other ontology service definitions
- Ontology Lookup Service (OLS) at the EBI. According to the website, the OLS can integrate any ontology available in OBO format. OLS is implemented as a web-service. The website has documentation on
- web-service API (representing the WSDL) with JavaDoc for the interface contract, and
- implementation overview (architecture)
- OLS also provides 3 ReST-style services, similar to some of the lookups described above. These queries return a simple key-value XML format.
- Term info: http://www.ebi.ac.uk/ontology-lookup/ajax.view?q=termmetadata&termid=ID&ontologyname=LABEL
- Completion list: http://www.ebi.ac.uk/ontology-lookup/ajax.view?q=termautocomplete&termname=NAME&ontologyname=LABEL
- Term name for ID: http://www.ebi.ac.uk/ontology-lookup/ajax.view?q=termname&termid=ID&ontologyname=LABEL
- The NCBO BioPortal supports a SOAP-based web-service API:
- The Zthes profile for SRU is a specification for navigating and querying remote thesauri
- SRU is a Library of Congress-sponsored standard for query interoperability between digital repositories
- The Zthes profile for SRU is based on an abstract model for thesaurus representation, which is also available as an XML Schema implementation.
- Finalize list of services for the ontology data service API.
- This will be an initial revision 1.0 - we'll surely have iterations later down the road.
- We'll need an acronym - anyone had a flash of creativity? What about OBODS
- Define which services are mandatory, and which are optional.
- Decide on protocol and query syntax.
- What about using REST, e.g., http://onto.myorg.edu/obods?q=list_ontology&category=anatomy, or using paths http://onto.myorg.edu/obods/ontology/list?category=anatomy)
- Create a reference implementation for the server.
- A very generic reference implementation would be a wrapper over a SPARQL endpoint, i.e., translating API calls into SPARQL queries and transforming returned RDF into the required format.
Richard G Côté, Philip Jones, Rolf Apweiler, Henning Hermjakob
The Ontology Lookup Service, a lightweight cross-platform tool for controlled vocabulary queries.
BMC Bioinformatics: 2006, 7;97
[PubMed:16507094] [WorldCat.org] [DOI] (I e)