Difference between revisions of "Project Plan"

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(Aims and working groups)
 
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Much of the schedule below is based on the [[MEDIA:Phenoscape_Project description_refs.pdf|1 July 2011 funded NSF grant]].  Our development schedule is revised as shown in the figure below in concert with budget cuts.  Relative to the original proposal the support for curation, particularly in the model organism databases, is significantly reduced.  This will impact our ability to respond as any problems arise with integration of the evolutionary data and somewhat compromise our ability to rigorously evaluate the tools being developed. Additionally, we will scale back the development goals for the semantic similarity search engine, focussing our efforts on achieving scalability and speedup.  We have also frontloaded the plans for execution of the NLP work to achieve a scalable workflow as early as possible in the process.
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__TOC__
[[Image:Phenoscape2fig.png|center|800px]]
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= Goals in progress, coming up, and scheduled =
  
=1. Scalable workflow (Hong)=
+
We are keeping our high-level goals, milestones, and deliverables in a [https://trello.com/b/xYkl0qmC public Trello Board]. (Click this link to get the board in its own window.)
Curation of legacy phenotypes from the literature is a major bottleneck. The overall objective of this part of our work is to improve the efficiency with which curators can find accurate terms, add missing terms, etc.
 
  
Primary personnel: Hong Cui, Jim, Todd, UNC postdoc, MS student
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<embedurl>https://trello.com/b/xYkl0qmC</embedurl>
=== Target milestone: First quarter: October 1, 2011  ===
 
Objective: Develop NLP to generate potential ontology terms and candidate EQ's in Phenex
 
* Generate list of terms to be added to ontologies (Hong)
 
* Evaluate accuracy of automated EQs on 50 character test set, refine testing set and methodology, begin development of Phenex ‘EQ suggestion’ interface requirements/specifications
 
* Identify corpus of publications, extract character descriptions
 
* Generate entities and qualities that can be identified, with frequency and ontology match
 
  
Action items:
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= Aims and working groups =
*Wasila to send Hong the PDFs containing characters from the 50 char list - done
 
*Action item: Wasila to send Paul a curated pub
 
*Action Item: Jim will send Hong full database report with character text and EQ assignments
 
*Jim: to enumerate pros and cons for MX (web-based) and Phenex for first phone call, estimate development time
 
*Hong: Hire MS student at AZ
 
*Todd: Hire UNC postdoc
 
  
=== Target milestone: Second quarter: January 1, 2012  ===
+
; 1. Scalable workflow :
=== Target milestone: End of Year 1:July 1, 2012  ===
 
=== Target milestone: Year 2:July 1, 2013  ===
 
=== Target milestone: Year 3:July 1, 2014  ===
 
=== Target milestone: Year 4:July 1, 2015  ===
 
  
==Term broker, in collaboration with NCBO (Hilmar) ==
+
:; 1.1 NLP in aid of ontology building and EQ annotation : Curation of legacy phenotypes from the literature is a major bottleneck. The overall objective of this part of our work is to improve the efficiency with which curators can find accurate terms, add missing terms, etc.
=== Target milestone: First quarter: October 1, 2011  ===
+
::* Participants: '''Hong Cui''' (lead), Jim, Todd, Wasila, Judy, Hong's MS student Zilong Chang, Paula
=== Target milestone: Second quarter: January 1, 2012  ===
 
=== Target milestone: End of Year 1:July 1, 2012  ===
 
=== Target milestone: Year 2:July 1, 2013  ===
 
=== Target milestone: Year 3:July 1, 2014  ===
 
=== Target milestone: Year 4:July 1, 2015  ===
 
  
=2. Ontology development and coordination (Wasila)=
+
:; 1.2 Term broker, in collaboration with NCBO : The overall goal here is to obtain temporary ID for anatomy ontology terms, communicate it to Phenex, and automatically replace with permanent terms when available.
==Anatomy ontologies==
+
::* Participants: '''Jim''' (lead), Natasha, Hilmar, Judy, Wasila
==Taxonomy ontologies==
 
  
=3. Phenotype annotation=
+
; 2. Ontology development and coordination:
==Evolutionary phenotypes (Paula)==
 
The objective is to transform the characters and character states from published phylogenetic studies into ontology-based descriptions ('Evolutionary phenotypes'), with a focus on fin and limb morphology.  This will require the development of a list of papers to be curated, re-evaluation of software curation tool, training of personnel in use of curation software and ontology development, and development of appropriate ontologies.
 
  
Personnel: Paula*, David, Paul, Wasila, Jim, and postdoctoral fellows
+
:; 2.1 Anatomy ontologies : The objective is to coordinate the development and alignment of multispecies and single species ontologies for vertebrates.  The lead curators of the zebrafish, Xenopus, and mouse anatomy ontologies, the teleost and amphibian multi-species ontologies, and the proposed amniote anatomy ontology will meet regularly to review terms from the skeletal branch, and update and synchronize ontologies accordingly. The focus of ontology development in year 1 is the limb/fin skeletal branch. Specific ontology development plans are [[Ontologies | here]] and Ontology development workflow is [[Ontology workflow | here]].
*Coordinator
+
::* Participants: '''Wasila''' lead), Nizar, Lauren, Paul, David, Terry, Yvonne, Ceri, Christina, VG, Paula, Chris
  
=== Target milestone: First quarter: October 1, 2011 ===
+
:; 2.2 Vertebrate Taxonomy Ontology : The objective is to develop a taxonomic ontology that includes all fossil and extant vertebrate taxa from community-vetted sources (PBDB, Paul's database, AmphibiaWeb). This ontology is required for curation of phenotypes and querying.
Objective: Develop a prioritized list of phylogenetic papers containing vertebrate fin/limb data for curation; evaluate curation tool; prepare KB for vertebrate data
+
::* Participants: '''Peter''' (lead), Paul, David, Nizar, Wasila
  
Action items:
+
:; 2.3 Sync Tool :
* Develop a list of priority papers (pdfs) to be curated. --[[User:Pmabee@usd.edu|Pmabee@usd.edu]] 10:37, 10 October 2011 (EDT) Done in Mendeley except archosaurs
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::* Participants: '''Jim''' (lead), Wasila, Chris, Ceri, Yvonne
* Annotation for AmAO to begin after AmAO developed (August 2011)
 
* Training (ontology editor; annotation tool) for Paul & Nizar at NESCent
 
* Paul and Nizar will document in lists any additional terms and definitions before meeting; prepare to add them to AmAO at NESCent.
 
* Evaluate curation tool - do we need a new one?
 
* Jim will develop KB instance in parallel for Vertebrates (a new beta) this summer
 
  
=== Target milestone: Second quarter: January 1, 2012  ===
+
; 3. Phenotype annotation :
=== Target milestone: End of Year 1:July 1, 2012  ===
 
  
=== Target milestone: Year 2: July 1, 2013 ===
+
:; 3.1 Evolutionary phenotypes : The objective is to transform the characters and character states from published phylogenetic studies into ontology-based descriptions ('Evolutionary phenotypes'), with a focus on fin and limb morphology. This will require the development of a list of papers to be curated, re-evaluation of software curation tool, training of personnel in use of curation software and ontology development, and development of appropriate ontologies. Annotation workflow is described [[Curation workflow | here.]]
* Annotation for AAO to begin in Year 2 (after cloning XAO)
+
::* Participants: '''Paula''' (lead), David, Paul, Wasila, Jim, Nizar
=== Target milestone: Year 3: July 1, 2014  ===
 
=== Target milestone: Year 4: July 1, 2015  ===
 
  
==Model organism phenotypes (Monte) ==
+
:; 3.2 Model organism phenotypes (Monte) : To annotate the skeletal phenotypes for fin and limb for genetic mutants of zebrafish, Xenopus, and mouse. The model organism (MOD) curators will initially prioritize comprehensive annotation of skeletal phenotypes for the fin and limb, and subsequently of skeletal phenotypes in general.
Objective: To annotate the skeletal phenotypes for fin and limb for genetic mutants of zebrafish, Xenopus, and mouse. The model organism (MOD) curators will initially prioritize comprehensive annotation of skeletal phenotypes for the fin and limb, and subsequently of skeletal phenotypes in general.
+
::* Participants: '''Monte''' (lead), ZFIN (Monte, Ceri,Yvonne), Xenbase (Aaron, Christina), MGI (Judy, Terry)
  
Involved personnel: ZFIN (Monte*, Ceri,Yvonne), Xenbase (Aaron, Christina), MGI (Judy, Terry)
+
; 4. Homology : The legacy homology assertions for the fin-limb skeleton, including assertions of both phylogenetic and iterative (serial) homology, and the genes involved in growth and patterning of the limb at various stages, e.g., Bmps, Fgfs, Gdf5, Sox9 are also well known.
* coordinator
+
:* Participants: '''Hilmar''' (lead), Chris, Paula, David, Paul, Nizar
  
=== Target milestone: First quarter: October 1, 2011  ===
+
; 5. Semantic similarity search engine (aka Phenoblast) : Provide the ability for users to take a phenotype collection (of terms) and look across all collections for those that semantically match the terms. Like BLAST, highest ‘hits’ would be ranked first, and user could drill down.
* Curation of expression and phenotypes
+
:* Participants: '''Todd''' (lead), Hilmar, Jim, Chris, Judy, Paula, Peter
* Investigate additional funding through NSF (Todd) and NIH (Monte, Judy)
 
* Determine whether the current MP->EQ mapping is sufficient (i.e., the mapping that had been done with
 
George)? In particular, is the limb and limb girdle mapping complete?
 
  
Action items:
+
; 6. Knowledgebase reasoning and development :
* Judy will check with Martin to see if limb mapping has done
+
:* Participants: '''Hilmar''' (lead), Todd, Jim, Chris, Paula, Wasila and others for UI development
* Determine who is responsible for completing the mapping and keeping it up to date? Cindy?  How to coordinate with PATO?
 
* Are there outstanding problems with developmental phenotypes for mouse, i.e. how to incorporate the abstract mouse?
 
* Determine timeline for:
 
** Developing pipelines for uploading Xenbase and MGI phenotype data to Phenoscape
 
** Incorporating expression data into Phenoscape KB
 
  
=== Target milestone: Second quarter: January 1, 2012  ===
+
; 7. Capstone : As a capstone, in years 3 and 4 of the project, we will validate the capabilities of the above suite of tools by testing how well known developmental pathways for the well-studied fin/limb skeletal transition in vertebrate evolution are identified and how well it scales to a datastore containing billions of phenotypes.
=== Target milestone: End of Year 1:July 1, 2012  ===
+
:* Participants: '''Todd''' (lead), everyone in project
=== Target milestone: Year 2: July 1, 2013  ===
 
* In year 2, Xenbase will begin curating phenotypes
 
 
 
=== Target milestone: Year 3: July 1, 2014  ===
 
=== Target milestone: Year 4: July 1, 2015  ===
 
 
 
=4. Homology (Paula to fill in and check with Hilmar)=
 
==Homology reasoning==
 
==Homology assertions==
 
 
 
=5. Semantic similarity search engine (aka Phenoblast) and OBD/OWL (Todd, Jim? to fill in)=
 
 
 
=6. Knowledgebase reasoning and development
 
 
 
=7. Capstone=
 
==component 1==
 
  
 +
= NSF Phenoscape project abstracts =
 +
DBI 1062404 and 1062542: Collaborative research: ABI Development: Ontology-enabled reasoning across phenotypes from evolution and model organisms
  
 +
1. Technical description of the project.
  
 
DBI 1062404 and 1062542: Collaborative research: ABI Development: Ontology-enabled reasoning across phenotypes from evolution and model organisms
 
1. Technical description of the project.
 
 
An award is made to the University of South Dakota and the University of North Carolina to develop ontology-driven tools for machine reasoning over large volumes of phenotype data.  A fast semantic similarity engine will be developed to allow searches for evolutionary transitions and mutant genes characterized by similar phenotypic profiles.  An ontological framework for reasoning over homology will be developed to allow rigorous reasoning over evolutionary diverse lineages.  Natural language processing tools will be developed to improve upon the efficiency of mining phenotype data from the literature and improving data consistency. This suite of tools will be tested on a large number of skeletal phenotypes from diverse fossil and modern vertebrates.  Taxonomic and anatomical ontologies for vertebrates will be augmented and hypotheses of anatomical homology formally encoded.  The ontologies and software tools, together with phenotypes extracted from the vertebrate systematic literature, will be integrated in the knowledgebase with genetic and phenotype data from three vertebrate model organisms: zebrafish (Danio rerio),  African clawed frog (Xenopus laevis), and mouse (Mus musculus).  The knowledgebase will be exposed to generic reasoners using semantic web standards.  The system will be validated by its success in retrieving candidate genes for the well-studied vertebrate fin-limb transition and other major events in skeletal evolution.
 
An award is made to the University of South Dakota and the University of North Carolina to develop ontology-driven tools for machine reasoning over large volumes of phenotype data.  A fast semantic similarity engine will be developed to allow searches for evolutionary transitions and mutant genes characterized by similar phenotypic profiles.  An ontological framework for reasoning over homology will be developed to allow rigorous reasoning over evolutionary diverse lineages.  Natural language processing tools will be developed to improve upon the efficiency of mining phenotype data from the literature and improving data consistency. This suite of tools will be tested on a large number of skeletal phenotypes from diverse fossil and modern vertebrates.  Taxonomic and anatomical ontologies for vertebrates will be augmented and hypotheses of anatomical homology formally encoded.  The ontologies and software tools, together with phenotypes extracted from the vertebrate systematic literature, will be integrated in the knowledgebase with genetic and phenotype data from three vertebrate model organisms: zebrafish (Danio rerio),  African clawed frog (Xenopus laevis), and mouse (Mus musculus).  The knowledgebase will be exposed to generic reasoners using semantic web standards.  The system will be validated by its success in retrieving candidate genes for the well-studied vertebrate fin-limb transition and other major events in skeletal evolution.
  
 
2. Non-technical explanation of the project's broader significance and importance.
 
2. Non-technical explanation of the project's broader significance and importance.
 +
 
Human-readable descriptions of “phenotypic” properties such as anatomy and behavior are not well-suited to computational analysis.  Yet, in evolutionary biology, genetics and development, computational assistance is necessary to discover patterns within the enormous volumes of descriptive phenotype data that are being reported in the literature and in online databases.  Ontologies are structured, controlled vocabularies that can be applied to collections of descriptive data to permit logical reasoning to be used. Using the evolutionary transition from fins to limbs as a test system, this project will develop ontologically-aware software that allows users to discover similar sets of phenotypes for different taxa or mutant genes within large and diverse datasets.  The evolutionary breadth of the test data requires the development of a rigorous framework for reasoning over hypotheses of homology.  Another goal is to develop and evaluate natural language processing tools for efficiently capturing ontological descriptions of phenotype from the descriptions available in the published literature. Phenotype data from the systematic literature for both extinct and extant vertebrates will be combined with mutant phenotype data from three vertebrate genetic models: zebrafish (Danio rerio), frog (Xenopus laevis), and mouse (Mus musculus).  The suite of tools will be validated by recovering developmental genetic pathways that underlie the evolutionary transition from fin to limb in vertebrates, and refined by iterative testing with domain bioinformaticians on the project and biologists from the broader user community.
 
Human-readable descriptions of “phenotypic” properties such as anatomy and behavior are not well-suited to computational analysis.  Yet, in evolutionary biology, genetics and development, computational assistance is necessary to discover patterns within the enormous volumes of descriptive phenotype data that are being reported in the literature and in online databases.  Ontologies are structured, controlled vocabularies that can be applied to collections of descriptive data to permit logical reasoning to be used. Using the evolutionary transition from fins to limbs as a test system, this project will develop ontologically-aware software that allows users to discover similar sets of phenotypes for different taxa or mutant genes within large and diverse datasets.  The evolutionary breadth of the test data requires the development of a rigorous framework for reasoning over hypotheses of homology.  Another goal is to develop and evaluate natural language processing tools for efficiently capturing ontological descriptions of phenotype from the descriptions available in the published literature. Phenotype data from the systematic literature for both extinct and extant vertebrates will be combined with mutant phenotype data from three vertebrate genetic models: zebrafish (Danio rerio), frog (Xenopus laevis), and mouse (Mus musculus).  The suite of tools will be validated by recovering developmental genetic pathways that underlie the evolutionary transition from fin to limb in vertebrates, and refined by iterative testing with domain bioinformaticians on the project and biologists from the broader user community.
  
 
3. Indicate how your project addresses criteria specific to Development
 
3. Indicate how your project addresses criteria specific to Development
 +
 
A broad community of users will participate through the lifecycle of this project in the development of community standards and resources for the interoperability and computability of phenotypic knowledge. This will be achieved through workshops, usability testing sessions, and coordination with key research networks.  Stakeholder ownership will be enhanced by rapid and open release of a variety of products that we anticipate to be of immediate and enduring value to the greater biology community, including tools for streamlining data curation and performing large-scale semantic similarity searches, high quality vertebrate taxonomy and anatomy ontologies, and standards for reasoning over homology.  We will provide a unique training environment for students, postdocs and summer interns, including Native Americans through outreach at the University of South Dakota and minority and female students though a collaboration with Project Exploration at the University of Chicago.  Project progress and outcomes will be disseminated through both traditional and online outlets for scholarly communication (including blog posts at mailing lists); the primary web presence will be at https://www.phenoscape.org/wiki/.
 
A broad community of users will participate through the lifecycle of this project in the development of community standards and resources for the interoperability and computability of phenotypic knowledge. This will be achieved through workshops, usability testing sessions, and coordination with key research networks.  Stakeholder ownership will be enhanced by rapid and open release of a variety of products that we anticipate to be of immediate and enduring value to the greater biology community, including tools for streamlining data curation and performing large-scale semantic similarity searches, high quality vertebrate taxonomy and anatomy ontologies, and standards for reasoning over homology.  We will provide a unique training environment for students, postdocs and summer interns, including Native Americans through outreach at the University of South Dakota and minority and female students though a collaboration with Project Exploration at the University of Chicago.  Project progress and outcomes will be disseminated through both traditional and online outlets for scholarly communication (including blog posts at mailing lists); the primary web presence will be at https://www.phenoscape.org/wiki/.
  
 
[[Category:Project Management]]
 
[[Category:Project Management]]
 
[[Category:Software]]
 
[[Category:Software]]

Latest revision as of 17:11, 28 August 2012

Goals in progress, coming up, and scheduled

We are keeping our high-level goals, milestones, and deliverables in a public Trello Board. (Click this link to get the board in its own window.)

<embedurl>https://trello.com/b/xYkl0qmC</embedurl>

Aims and working groups

1. Scalable workflow 
1.1 NLP in aid of ontology building and EQ annotation 
Curation of legacy phenotypes from the literature is a major bottleneck. The overall objective of this part of our work is to improve the efficiency with which curators can find accurate terms, add missing terms, etc.
  • Participants: Hong Cui (lead), Jim, Todd, Wasila, Judy, Hong's MS student Zilong Chang, Paula
1.2 Term broker, in collaboration with NCBO 
The overall goal here is to obtain temporary ID for anatomy ontology terms, communicate it to Phenex, and automatically replace with permanent terms when available.
  • Participants: Jim (lead), Natasha, Hilmar, Judy, Wasila
2. Ontology development and coordination
2.1 Anatomy ontologies 
The objective is to coordinate the development and alignment of multispecies and single species ontologies for vertebrates. The lead curators of the zebrafish, Xenopus, and mouse anatomy ontologies, the teleost and amphibian multi-species ontologies, and the proposed amniote anatomy ontology will meet regularly to review terms from the skeletal branch, and update and synchronize ontologies accordingly. The focus of ontology development in year 1 is the limb/fin skeletal branch. Specific ontology development plans are here and Ontology development workflow is here.
  • Participants: Wasila lead), Nizar, Lauren, Paul, David, Terry, Yvonne, Ceri, Christina, VG, Paula, Chris
2.2 Vertebrate Taxonomy Ontology 
The objective is to develop a taxonomic ontology that includes all fossil and extant vertebrate taxa from community-vetted sources (PBDB, Paul's database, AmphibiaWeb). This ontology is required for curation of phenotypes and querying.
  • Participants: Peter (lead), Paul, David, Nizar, Wasila
2.3 Sync Tool 
  • Participants: Jim (lead), Wasila, Chris, Ceri, Yvonne
3. Phenotype annotation 
3.1 Evolutionary phenotypes 
The objective is to transform the characters and character states from published phylogenetic studies into ontology-based descriptions ('Evolutionary phenotypes'), with a focus on fin and limb morphology. This will require the development of a list of papers to be curated, re-evaluation of software curation tool, training of personnel in use of curation software and ontology development, and development of appropriate ontologies. Annotation workflow is described here.
  • Participants: Paula (lead), David, Paul, Wasila, Jim, Nizar
3.2 Model organism phenotypes (Monte) 
To annotate the skeletal phenotypes for fin and limb for genetic mutants of zebrafish, Xenopus, and mouse. The model organism (MOD) curators will initially prioritize comprehensive annotation of skeletal phenotypes for the fin and limb, and subsequently of skeletal phenotypes in general.
  • Participants: Monte (lead), ZFIN (Monte, Ceri,Yvonne), Xenbase (Aaron, Christina), MGI (Judy, Terry)
4. Homology 
The legacy homology assertions for the fin-limb skeleton, including assertions of both phylogenetic and iterative (serial) homology, and the genes involved in growth and patterning of the limb at various stages, e.g., Bmps, Fgfs, Gdf5, Sox9 are also well known.
  • Participants: Hilmar (lead), Chris, Paula, David, Paul, Nizar
5. Semantic similarity search engine (aka Phenoblast) 
Provide the ability for users to take a phenotype collection (of terms) and look across all collections for those that semantically match the terms. Like BLAST, highest ‘hits’ would be ranked first, and user could drill down.
  • Participants: Todd (lead), Hilmar, Jim, Chris, Judy, Paula, Peter
6. Knowledgebase reasoning and development 
  • Participants: Hilmar (lead), Todd, Jim, Chris, Paula, Wasila and others for UI development
7. Capstone 
As a capstone, in years 3 and 4 of the project, we will validate the capabilities of the above suite of tools by testing how well known developmental pathways for the well-studied fin/limb skeletal transition in vertebrate evolution are identified and how well it scales to a datastore containing billions of phenotypes.
  • Participants: Todd (lead), everyone in project

NSF Phenoscape project abstracts

DBI 1062404 and 1062542: Collaborative research: ABI Development: Ontology-enabled reasoning across phenotypes from evolution and model organisms

1. Technical description of the project.

An award is made to the University of South Dakota and the University of North Carolina to develop ontology-driven tools for machine reasoning over large volumes of phenotype data. A fast semantic similarity engine will be developed to allow searches for evolutionary transitions and mutant genes characterized by similar phenotypic profiles. An ontological framework for reasoning over homology will be developed to allow rigorous reasoning over evolutionary diverse lineages. Natural language processing tools will be developed to improve upon the efficiency of mining phenotype data from the literature and improving data consistency. This suite of tools will be tested on a large number of skeletal phenotypes from diverse fossil and modern vertebrates. Taxonomic and anatomical ontologies for vertebrates will be augmented and hypotheses of anatomical homology formally encoded. The ontologies and software tools, together with phenotypes extracted from the vertebrate systematic literature, will be integrated in the knowledgebase with genetic and phenotype data from three vertebrate model organisms: zebrafish (Danio rerio), African clawed frog (Xenopus laevis), and mouse (Mus musculus). The knowledgebase will be exposed to generic reasoners using semantic web standards. The system will be validated by its success in retrieving candidate genes for the well-studied vertebrate fin-limb transition and other major events in skeletal evolution.

2. Non-technical explanation of the project's broader significance and importance.

Human-readable descriptions of “phenotypic” properties such as anatomy and behavior are not well-suited to computational analysis. Yet, in evolutionary biology, genetics and development, computational assistance is necessary to discover patterns within the enormous volumes of descriptive phenotype data that are being reported in the literature and in online databases. Ontologies are structured, controlled vocabularies that can be applied to collections of descriptive data to permit logical reasoning to be used. Using the evolutionary transition from fins to limbs as a test system, this project will develop ontologically-aware software that allows users to discover similar sets of phenotypes for different taxa or mutant genes within large and diverse datasets. The evolutionary breadth of the test data requires the development of a rigorous framework for reasoning over hypotheses of homology. Another goal is to develop and evaluate natural language processing tools for efficiently capturing ontological descriptions of phenotype from the descriptions available in the published literature. Phenotype data from the systematic literature for both extinct and extant vertebrates will be combined with mutant phenotype data from three vertebrate genetic models: zebrafish (Danio rerio), frog (Xenopus laevis), and mouse (Mus musculus). The suite of tools will be validated by recovering developmental genetic pathways that underlie the evolutionary transition from fin to limb in vertebrates, and refined by iterative testing with domain bioinformaticians on the project and biologists from the broader user community.

3. Indicate how your project addresses criteria specific to Development

A broad community of users will participate through the lifecycle of this project in the development of community standards and resources for the interoperability and computability of phenotypic knowledge. This will be achieved through workshops, usability testing sessions, and coordination with key research networks. Stakeholder ownership will be enhanced by rapid and open release of a variety of products that we anticipate to be of immediate and enduring value to the greater biology community, including tools for streamlining data curation and performing large-scale semantic similarity searches, high quality vertebrate taxonomy and anatomy ontologies, and standards for reasoning over homology. We will provide a unique training environment for students, postdocs and summer interns, including Native Americans through outreach at the University of South Dakota and minority and female students though a collaboration with Project Exploration at the University of Chicago. Project progress and outcomes will be disseminated through both traditional and online outlets for scholarly communication (including blog posts at mailing lists); the primary web presence will be at https://www.phenoscape.org/wiki/.