Ontology Data Service API

Overview

Data services have been implemented as part of the Phenoscape application to retrieve data about evolutionary and model organism phenotypes. Ancillary services function in the auto completion of partially entered search terms by retrieving matching terms from the database, query relevant summary information on search terms, and retrieve any stored homology information about the search terms. This page details the functioning of each of these services, which make up the very first implementation of the Phenoscape application.

Service definitions

Auto completion Service

1. Auto completion for term being typed in search field
   • Function: lookup the ontologies being served by the data service
   • Input: none, or a particular name, and/or the name of the ontology category
   • Output: a record of name, version, identifier, meta-data (e.g., retired? in production? purpose?) for each ontology being served
2. Look up term
   • Function: Obtain the full term information for a given ID
   • Input: a term ID, or the combination of a term name and ontology ID
   • Output: the matching term in OBO or RDF/OWL format
   • Notes: do we need neighborhood here too (e.g., with IDs only); OBO only has parents, not children.
3. Completion list
   • Function: Obtain matching term names for a partial term name string
   • Input: partial term name string, a list of ontology IDs, search parameters (search names only or synonyms only or both, search obsoletes or not, search definition or not)
   • Output: matches as records of term name, term ID, ontology ID, synonym that was hit, how the term was hit (name, synonym, or definition)
4. Neighborhood graph
   • Function: Obtain parents, children, descendants, or ancestors for a given term
   • Input: term ID, list of relationships to include or exclude, number of levels (path length) up and down to include
   • Output: list of terms in OBO or RDF format
   • Note: Is it sensible to return a graph as OBO format? Do we need to mandate the semantics of matching mixed-type paths (e.g., is-a and part-of)?
5. Downloading ontology
   • Function: Obtain all terms and relationships comprising an ontology
   • Input: ontology ID, optionally name of the slim
   • Output: the ontology as an OBO or OWL stream of text
   • Notes: do we need a parameter for specifying the desired format? do we need parameter for including obsoletes or not
6. SPARQL endpoint
   • Function: Issue SPARQL queries and obtain the results in RDF
   • Input:
   • Output:

Notes applicable to all:

• Do we need to add search parameter to specify the 'slim' for each service that involves specifying an ontoloy?
• Should we have a protocol for client and server negotiating the desired return format, or should this be a parameter (in which case we also need a method to obtain all supported formats from the server)?

Phenotype Data Service

1. Login
   • Function: Given a username and secret, obtain an authentication token
   • Input:
   • Output:
2. Save EQ statements
   • Function: Save an array of EQ statements to the data store
   • Input: a list of EQ statements on OBD-xml or pheno-xml format
   • Output: success/failure indicator
3. Load EQ statements
   • Function: Load an array of EQ statements from the data store
   • Input: author, or list of taxa,
   • Output: matching EQ statements in pheno-xml or pheno-syntax format
   • Notes: do we need parameter of list of entities to obtain EQs for?

Query languages

• SPARQL

Data exchange formats

• Plain text over HTTP:
  • OBO format
  • YAML
  • JSON

• XML over HTTP:
  • OBO-XML format
  • OBD-XML format

• RDF over HTTP:
  • RDF/XML
  • RDF/N-triples

Other ontology service definitions

• Ontology Lookup Service (OLS) at the EBI. cote2006 According to the website, the OLS can integrate any ontology available in OBO format. OLS is implemented as a web-service. The website has documentation on
  • web-service API (representing the WSDL) with JavaDoc for the interface contract, and
  • implementation overview (architecture)
  • OLS also provides 3 ReST-style services, similar to some of the lookups described above. These queries return a simple key-value XML format.
    • Term info: http://www.ebi.ac.uk/ontology-lookup/ajax.view?q=termmetadata&termid=ID&ontologyname=LABEL
    • Completion list: http://www.ebi.ac.uk/ontology-lookup/ajax.view?q=termautocomplete&termname=NAME&ontologyname=LABEL
    • Term name for ID: http://www.ebi.ac.uk/ontology-lookup/ajax.view?q=termname&termid=ID&ontologyname=LABEL
• The NCBO BioPortal supports a SOAP-based web-service API:
  • WSDL: http://www.bioontology.org/ncboservicebeans/NCBOWebserviceBean?wsdl
  • Java JUnit test: test.webservice.NCBOServiceTest
• The Zthes profile for SRU is a specification for navigating and querying remote thesauri
  • SRU is a Library of Congress-sponsored standard for query interoperability between digital repositories
  • The Zthes profile for SRU is based on an abstract model for thesaurus representation, which is also available as an XML Schema implementation.

Next Steps

1. Finalize list of services for the ontology data service API.
   • This will be an initial revision 1.0 - we'll surely have iterations later down the road.
   • We'll need an acronym - anyone had a flash of creativity? What about OBODS
2. Define which services are mandatory, and which are optional.
3. Decide on protocol and query syntax.
   • What about using REST, e.g., http://onto.myorg.edu/obods?q=list_ontology&category=anatomy, or using paths http://onto.myorg.edu/obods/ontology/list?category=anatomy)
4. Create a reference implementation for the server.
   • A very generic reference implementation would be a wrapper over a SPARQL endpoint, i.e., translating API calls into SPARQL queries and transforming returned RDF into the required format.
5. Create a reference implementation for a web-application client (using JavaScript) and for, e.g., a Java client (for servlets or Java stand-alone apps).

References

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1. cote2006 pmid=16507094

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