Difference between revisions of "Phenoscape data repository"

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== Data Repository ==
 
== Data Repository ==
  
The Phenoscape data repository has been implemented as a [http://www.postgresql.org/ PostgreSQL] relational database, and at present is housed on the development database server at NESCent.
+
The Phenoscape data repository has been implemented as a [http://www.postgresql.org/ PostgreSQL] relational database, and at present is housed on a dedicated database server.
  
 
== Schema ==
 
== Schema ==
Line 85: Line 85:
 
# Annotations from a set of selected publications, which describe in rich-text unstructured format, the observed phenotypes of about 25000 different species of fish belonging to the clade of Ostariophysi. These annotations are entered by curators using the [[Phenex]] annotation tool and are saved in the [[http://www.nexml.org/ NeXML]] data format.
 
# Annotations from a set of selected publications, which describe in rich-text unstructured format, the observed phenotypes of about 25000 different species of fish belonging to the clade of Ostariophysi. These annotations are entered by curators using the [[Phenex]] annotation tool and are saved in the [[http://www.nexml.org/ NeXML]] data format.
  
The [[Phenoscape data loader]] can be accessed through the 'Phenoscape' folder of the [https://obo.svn.sourceforge.net/svnroot/obo/OBDAPI/trunk OBDAPI project]. A complete database refresh can be started off by running the "refresh-database" target in the Ant build file.
+
A complete database refresh using the  [[Phenoscape data loader]] can be started off by running the "refresh-database" target in the Ant build file in the 'Phenoscape' folder of the [https://obo.svn.sourceforge.net/svnroot/obo/OBDAPI/trunk OBDAPI project].
  
 
== Querying the data ==
 
== Querying the data ==
  
A rich library of methods has been inherited from the OBD project to execute various generic queries on the database. This is being [[Queries|extended]] currently to conform to the very specific requirements of the Phenoscape project.
+
Queries have been implemented for retrieving phenotype information (summaries and details), homology information, summaries of search terms, metadata about phenotype assertions, and auto complete suggestions for search terms as they are being entered. Data retrieved by these queries are accessed by the various [[Data Services | Phenoscape data services]]. The details about these queries are presented here.
 +
 
 +
===Relations of interest===
 +
 
 +
This section discusses the various entities and binary directed links between these entities, which are leveraged by the database queries. Assertions about the model organism (from ZFIN) and the evolutionary species are converted into the ''exhibits'' link specified in (1) below. Note the right hand side of the ''exhibits'' link. It is a post composition of an Entity and a Quality, which makes up a description of a phenotype.
 +
 
 +
<javascript>
 +
Taxon                              exhibits                              inheres_in(Quality, Entity)              --(1)
 +
</javascript>
 +
 
 +
The post composed phenotype is related to its components by the ''is_a'' and the ''inheres_in'' relation as shown in (2) and (3) below
 +
 
 +
<javascript>
 +
inheres_in(Quality, Entity)        inheres_in                            Entity                                    --(2)
 +
inheres_in(Quality, Entity)        is_a                                  Quality                                  --(3)
 +
</javascript>
 +
 
 +
The Quality is related to a Character by an inferred ''value_for'' relation as shown in (4)
 +
 
 +
<javascript>
 +
Quality                            value_for                            Character                                --(4)
 +
</javascript>
 +
 
 +
An example should make this clearer. Consider the statement, "In Siluriformes, the shape of the dorsal surface of the basihyal bone is flat or convex" from [Albert, 2001]. This statement can be represented as in (1ex) below. Note the similar form to (1). Siluriformes is the taxon, flat is the quality, and basihyal bone is the entity.
 +
 
 +
<javascript>
 +
Siluriformes                        exhibits                              inheres_in(flat, basihyal bone)          --(1ex)
 +
</javascript>
 +
 
 +
Now the post composed phenotype is related to its entity and quality components as in (2ex) and (3ex). Note the similarity to (2) and (3)
 +
 
 +
<javascript>
 +
inheres_in(flat, basihyal bone)    inheres_in                            basihyal bone                            --(2ex)
 +
inheres_in(flat, basihyal bone)    is_a                                  flat                                      --(3ex)
 +
</javascript>
 +
 
 +
Finally, the quality 'flat' is related to the character 'shape' by (4ex). Note that 'flat' is just one of the values for 'shape'. Other values my be 'rounded', 'curved', etc.
 +
 
 +
<javascript>
 +
flat                                value_for                            shape                                    --(4ex)
 +
</javascript>
 +
 
 +
Moving on, the database also stores provenance information (metadata) about the assertion that Siluriformes exhibits flat basihyal bones. AT the very minimum, we need to know the publication from which the assertion was extracted. If the curators have specifically cited the text from the publication which forms the basis of their assertion, we need to know that as well.
 +
 
 +
The database provides a handle to access this metadata from the assertion itself. The LINK table includes a reiflink_node_id attribute, from which publication, curator names, character and state text, and all other relevant metadata can be accessed. Without going into more database specific details, conceptually the statement (1ex) is linked to a reification identifer, which is linked to the actual metadata. Transparently, the statement (1ex) can be linked with a publication as shown in (5ex) below. The linkage to the other facets of the metadata is done similarly.
 +
 
 +
<javascript>
 +
(1ex)                              posited_by                            Albert, 2001                            --(5ex)
 +
</javascript>
 +
 
 +
The schema of the relations is shown below [[Image:PhenoscapeInTriples.jpg]]
  
 
===Speeding up the queries: The data warehouse===
 
===Speeding up the queries: The data warehouse===
Line 95: Line 145:
 
Queries used in the Phenoscape data services module were found to be intolerably slow in returning, esp. when asked to retrieve and [[Data_Services#Annotations_summary | summarize annotation data]] for genes and teleost species. The slow times in query execution were primarily due to the large numbers of JOINs in them, and the extensive volume of data, which needed to be processed in various facets of the query execution plan.
 
Queries used in the Phenoscape data services module were found to be intolerably slow in returning, esp. when asked to retrieve and [[Data_Services#Annotations_summary | summarize annotation data]] for genes and teleost species. The slow times in query execution were primarily due to the large numbers of JOINs in them, and the extensive volume of data, which needed to be processed in various facets of the query execution plan.
  
To address this issue, it was decided to create summaries of the annotations in the database in [[conceptual_schema | simple data warehouse tables]]. New queries which were tested on these summary tables executed much faster, having dispensed with the numerous JOINs between the [[#The_NODE_table | NODE]] and [[#The_LINK_table | LINK]] tables, aliased several times over.
+
To address this issue, it was decided to create summaries of the annotations in the database in simple data warehouse tables. New queries which were tested on these summary tables executed much faster, having dispensed with the numerous JOINs between the [[#The_NODE_table | NODE]] and [[#The_LINK_table | LINK]] tables, aliased several times over.
 +
 
 +
====[[conceptual_schema | The data warehouse schema ]]====
 +
 
 +
 
 +
 
 +
The data warehouse has been designed with the intent of maximizing the efficiency of queries executed on the Phenoscape knowledge base. For phenotype queries, we need to know the phenotype in question, the taxa or genes which are associated with that phenotype, as well as the entity and quality associated with that phenotype. We also need to find the character, which the quality is associated with. For example if the quality is ''reduced number of'', the character in question would be ''count''.
 +
 
 +
To effectively execute this query, the phenotype centric model of the data warehouse is designed as follows (concepts and attributes are capitalized). A taxon or gene may be associated with one or more PHENOTYPE(s) and a PHENOTYPE may be associated with one or more genes or taxa. A PHENOTYPE is associated with exactly one ENTITY and one QUALITY. A QUALITY may be associated with one or more PHENOTYPE(s). Further, a QUALITY is associated with exactly one CHARACTER, which is a QUALITY as well.
 +
 
 +
For queries for provenance data about taxon to phenotype assertions, we need to find the publication the assertion is extracted from, the specific text from the publication about character and state, as well as the curators' comments about the assertion.
 +
 
 +
To effectively execute these 'metadata' queries, the provenance data is modeled as an association attribute. For every instance of the association between a TAXON and a PHENOYPE, we capture CHARACTER. STATE, CURATORS, and PUBLICATION. The PUBLICATION entity with all its attributes is linked to the REIF entity, which is the link to the metadata of the TAXON and PHENOTYPE.
 +
 
 +
This data warehouse can be reduced to the logical schema shown below
 +
 
 +
<table width=500 align=left border=1>
 +
<tr><td align=left colspan=3><b>Gene</b></td></tr>
 +
<tr>
 +
  <td align=center>Gene_id {PK} </td>
 +
  <td align=center>Gene_Uid</td>
 +
  <td align=center>Gene_Label</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=500 align=left border=1>
 +
<tr><td align=left colspan=2><b>Gene_Alias</b></td></tr>
 +
<tr>
 +
  <td align=center>Gene_id{FK}</td>
 +
  <td align=center>Alias</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=500 align=left border=1>
 +
<tr><td align=left colspan=3><b>Genotype</b></td></tr>
 +
<tr>
 +
  <td align=center>Genotype_id{PK}</td>
 +
  <td align=center>Genotype_Uid</td>
 +
  <td align=center>Genotype_Label</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=700 align=left border=1>
 +
<tr><td align=left colspan=3><b>Taxon</b></td></tr>
 +
<tr>
 +
  <td align=center>Taxon_id {PK}</td>
 +
  <td align=center>Taxon_Uid</td>
 +
  <td align=center>Taxon_Label</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=700 align=left border=1>
 +
<tr><td align=left colspan=2><b>Taxon_Alias</b></td></tr>
 +
<tr>
 +
  <td align=center>Taxon_id {FK}</td>
 +
  <td align=center>Alias</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=700 align=left border=1>
 +
<tr><td align=left colspan=2><b>Taxon_Is_A_Taxon</b></td></tr>
 +
<tr>
 +
  <td align=center>Taxon_id{FK}</td>
 +
  <td align=center>Taxon_id{FK}</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=700 align=left border=1>
 +
<tr><td align=left colspan=3><b>Entity</b></td></tr>
 +
<tr>
 +
  <td align=center>Entity_Id {PK}</td>
 +
  <td align=center>Entity_Uid</td>
 +
  <td align=center>Entity_Label</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=700 align=left border=1>
 +
<tr><td align=left colspan=2><b>Entity_Is_A_Entity</b></td></tr>
 +
<tr>
 +
  <td align=center>Entity_Id {FK}</td>
 +
  <td align=center>Entity_Id {FK}</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=700 align=left border=1>
 +
<tr><td align=left colspan=2><b>Entity_Part_Of_Entity</b></td></tr>
 +
<tr>
 +
  <td align=center>Entity_Id {FK}</td>
 +
  <td align=center>Entity_Id {FK}</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=700 align=left border=1>
 +
<tr><td align=left colspan=3><b>Quality</b></td></tr>
 +
<tr>
 +
  <td align=center>Quality_Id {PK}</td>
 +
  <td align=center>Quality_Uid </td>
 +
  <td align=center>Quality_Label </td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=700 align=left border=1>
 +
<tr><td align=left colspan=7><b>Phenotype</b></td></tr>
 +
<tr>
 +
  <td align=center>Phenotype_Id {PK}</td>
 +
  <td align=center>Phenotype_Uid</td>
 +
  <td align=center>Inheres_In_Entity_id {FK}</td>
 +
  <td align=center>Towards_Entity_id {FK}</td>
 +
  <td align=center>Is_A_Quality_id {FK}</td>
 +
  <td align=center>Is_A_Character_id {FK}</td>
 +
  <td align=center>Has_count</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=300 align=left border=1>
 +
<tr><td align=left colspan=3><b>Gene_Genotype_Phenotype</b></td></tr>
 +
<tr>
 +
  <td align=center>Gene_Id {FK}</td>
 +
  <td align=center>Genotype_Id {FK}</td>
 +
  <td align=center>Phenotype_Id {FK}</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=300 align=left border=1>
 +
<tr><td align=left colspan=3><b>Taxon_Phenotype</b></td></tr>
 +
<tr>
 +
  <td align=center>Taxon_Id {FK}</td>
 +
  <td align=center>Phenotype_Id {FK}</td>
 +
  <td align=center>Reif_Id {FK}</td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=300 align=left border=1>
 +
<tr><td align=left colspan=5><b>Taxon_Phenotype_Metadata</b></td></tr>
 +
<tr>
 +
  <td align=center>Reif_Id {PK}</td>
 +
  <td align=center>Character_Text</td>
 +
  <td align=center>State_Text </td>
 +
  <td align=center>Curators </td>
 +
  <td align=center>Curator_Comments </td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=300 align=left border=1>
 +
<tr><td align=left colspan=7><b>Publication</b></td></tr>
 +
<tr>
 +
  <td align=center>Publication {PK}</td>
 +
  <td align=center>Primary_Title</td>
 +
  <td align=center>Secondary_Title </td>
 +
  <td align=center>Pages </td>
 +
  <td align=center>Volume </td>
 +
  <td align=center>Abstract </td>
 +
  <td align=center>Year </td>
 +
<tr>
 +
</table>
 +
<br><br><br><br>
 +
<table width=300 align=left border=1>
 +
<tr><td align=left colspan=2><b>Publication_Reif_id</b></td></tr>
 +
<tr>
 +
  <td align=center>Publication {FK}</td>
 +
  <td align=center>Reif_Id {FK}</td>
 +
<tr>
 +
</table>
  
 
[[Category:OBD]]
 
[[Category:OBD]]

Latest revision as of 21:46, 14 December 2009

The Phenoscape data repository is a relational database, which holds phenotypic data from the model organism Danio Rerio (Zebrafish) and the evolutionary organisms belong to the clade of Ostariophysi. This page describes the schema of this data repository and outlines the methods to load and query this data repository.

Data Repository

The Phenoscape data repository has been implemented as a PostgreSQL relational database, and at present is housed on a dedicated database server.

Schema

The schema of the Phenoscape data repository is based upon the Open Biomedical Database (OBD) data format developed at the Berkeley Bioinformatics Open-source Projects (BBOP). OBD is based upon the Resource Description Framework (RDF) format for capturing metadata about Web (and Semantic Web) resources such as Web pages and Web services.

The philosophy of OBD is to represent every conceptual entity, be it a type or a token (synonymously a class or an object, or a concept or an instance) or a relation definition, as a Node. Instances of relations between these nodes are represented as Statements, specifically Link Statements. OBD also allows for reification, which is vital to the life sciences with their emphasis on evidence codes and attributions (provenance). For this purpose, OBD provides Literal Statements (and Annotation Statements) to capture metadata about Nodes and Link Statements, such as the source publication, evidence codes, specimens used, and so forth.

Tables

Two relational tables are central to the schema of the Phenoscape data repository. These are: LINK and NODE. The SQL commands for the creation of these tables (and the others) can be found at this Phenoscape Sourceforge page.

The NODE table

The NODE table contains information about every concept such as its unique identifier, label, and source ontology. The NODE table contains this information about concepts extracted from the source Ontologies. In addition, it also holds information about scientific publications (in a rudimentary format which will be improved upon soon), the ontologies themselves, and the representation of phenotypes from the ZFIN and NeXML databases. It will be augmented in the future to hold information about collection specimens. The NODE table adds a unique identifier (generated from a sequence) of its own to every row. An excerpt of the row from the NODE table for the Gymnotiformes term is shown below

<javascript>

node_id |   uid    |     label     | metatype | source_id

+----------+---------------+----------+-----------

  46050 | TTO:1390 | Gymnotiformes | C        |      9630

</javascript>

  • The NODE_ID column holds the unique identifier generated by the Phenoscape database for this term
  • The UID column holds the identifier of this term that is obtained from the Teleost Taxonomy Ontology (TTO). The 'TTO' is the namespace prefix
  • The LABEL column displays the label for this term
  • The METATYPE column shows term is a Class (C). Other metatypes are Relation (R) and Instance (I).
  • The SOURCE_ID column holds the NODE_ID of the ontology from which the term was extracted. In this case, the source ontology is the TTO

The LINK table

The LINK table contains rows which represent Statements which link the Nodes to one another, and also the metadata about these Nodes. The excerpt below shows some of the rows in the LINK table about the Gymnotiformes term

<javascript>

link_id | node_id | predicate_id | object_id


+---------+--------------+-----------

  23854 |    9637 |          102 |     46050
  59897 |   45723 |          102 |     46050
  60223 |   46050 |          102 |     46160
 501448 |    9932 |          102 |     46050

</javascript>

  • The LINK_ID column shows the database generated identifier for the link
  • The NODE_ID column shows the Subject of the Statement (in RDF parlance). This ID the is database generated identifier for the concept Eigenmanniidae (TTO:10000005)
  • The PREDICATE_ID column shows the Predicate of the Statement. This ID is the database generated identifier for the relation OBO_REL:is_a.
  • The OBJECT_ID column shows the Object of the Statement which is the ID generated by the database for concept Gymnotiformes

In simple terms, a sub species of Gymnotiformes is displayed by this Statement as shown in the triple below

<javascript>

     Eigenmanniidae                                is_a                        Gymnotiformes

</javascript>

Similarly, The third row in the display shows that Gymnotiformes is an Otophysian as shown below

<javascript>

     Gymnotiformes                                is_a                        Otophysi

</javascript>

Other important tables

  • The ALIAS table keeps track of the various aliases (alternate labels) of the concepts and relations, which are sourced from the ontologies
  • The DESCRIPTION table stores rich text descriptions of the concepts and relations, which are extracted from the ontologies
  • The OBD_SCHEMA_METADATA stores metadata about OBD such as the version of the OBD format in use, and also the last refresh date and time for the database

Views

The Phenoscape data repository also generates several views from the tables. These views are used in querying the database, some of which are part of the OBDAPI

Procedures

Stored procedures are used in populating the database with defined terms from the ontologies, and with phenotypic descriptions obtained from curators. In addition, they are also used in generating inferences from the asserted data. In the future, stored procedures may be used as necessary for speedier data retrieval.

Loading the data

The repository will be periodically refreshed to include the latest ontology definitions and curated data. At present, curated data is obtained from two different source which are:

  1. The ZFIN data repository (model organism database) containing descriptions of mutant phenotypes and the related genes and genotypes of zebrafish. This data exists primarily as tab delimited simple text files
  2. Annotations from a set of selected publications, which describe in rich-text unstructured format, the observed phenotypes of about 25000 different species of fish belonging to the clade of Ostariophysi. These annotations are entered by curators using the Phenex annotation tool and are saved in the [NeXML] data format.

A complete database refresh using the Phenoscape data loader can be started off by running the "refresh-database" target in the Ant build file in the 'Phenoscape' folder of the OBDAPI project.

Querying the data

Queries have been implemented for retrieving phenotype information (summaries and details), homology information, summaries of search terms, metadata about phenotype assertions, and auto complete suggestions for search terms as they are being entered. Data retrieved by these queries are accessed by the various Phenoscape data services. The details about these queries are presented here.

Relations of interest

This section discusses the various entities and binary directed links between these entities, which are leveraged by the database queries. Assertions about the model organism (from ZFIN) and the evolutionary species are converted into the exhibits link specified in (1) below. Note the right hand side of the exhibits link. It is a post composition of an Entity and a Quality, which makes up a description of a phenotype.

<javascript> Taxon exhibits inheres_in(Quality, Entity) --(1) </javascript>

The post composed phenotype is related to its components by the is_a and the inheres_in relation as shown in (2) and (3) below

<javascript> inheres_in(Quality, Entity) inheres_in Entity --(2) inheres_in(Quality, Entity) is_a Quality --(3) </javascript>

The Quality is related to a Character by an inferred value_for relation as shown in (4)

<javascript> Quality value_for Character --(4) </javascript>

An example should make this clearer. Consider the statement, "In Siluriformes, the shape of the dorsal surface of the basihyal bone is flat or convex" from [Albert, 2001]. This statement can be represented as in (1ex) below. Note the similar form to (1). Siluriformes is the taxon, flat is the quality, and basihyal bone is the entity.

<javascript> Siluriformes exhibits inheres_in(flat, basihyal bone) --(1ex) </javascript>

Now the post composed phenotype is related to its entity and quality components as in (2ex) and (3ex). Note the similarity to (2) and (3)

<javascript> inheres_in(flat, basihyal bone) inheres_in basihyal bone --(2ex) inheres_in(flat, basihyal bone) is_a flat --(3ex) </javascript>

Finally, the quality 'flat' is related to the character 'shape' by (4ex). Note that 'flat' is just one of the values for 'shape'. Other values my be 'rounded', 'curved', etc.

<javascript> flat value_for shape --(4ex) </javascript>

Moving on, the database also stores provenance information (metadata) about the assertion that Siluriformes exhibits flat basihyal bones. AT the very minimum, we need to know the publication from which the assertion was extracted. If the curators have specifically cited the text from the publication which forms the basis of their assertion, we need to know that as well.

The database provides a handle to access this metadata from the assertion itself. The LINK table includes a reiflink_node_id attribute, from which publication, curator names, character and state text, and all other relevant metadata can be accessed. Without going into more database specific details, conceptually the statement (1ex) is linked to a reification identifer, which is linked to the actual metadata. Transparently, the statement (1ex) can be linked with a publication as shown in (5ex) below. The linkage to the other facets of the metadata is done similarly.

<javascript> (1ex) posited_by Albert, 2001 --(5ex) </javascript>

The schema of the relations is shown below

Error creating thumbnail: Unable to save thumbnail to destination

Speeding up the queries: The data warehouse

Queries used in the Phenoscape data services module were found to be intolerably slow in returning, esp. when asked to retrieve and summarize annotation data for genes and teleost species. The slow times in query execution were primarily due to the large numbers of JOINs in them, and the extensive volume of data, which needed to be processed in various facets of the query execution plan.

To address this issue, it was decided to create summaries of the annotations in the database in simple data warehouse tables. New queries which were tested on these summary tables executed much faster, having dispensed with the numerous JOINs between the NODE and LINK tables, aliased several times over.

The data warehouse schema

The data warehouse has been designed with the intent of maximizing the efficiency of queries executed on the Phenoscape knowledge base. For phenotype queries, we need to know the phenotype in question, the taxa or genes which are associated with that phenotype, as well as the entity and quality associated with that phenotype. We also need to find the character, which the quality is associated with. For example if the quality is reduced number of, the character in question would be count.

To effectively execute this query, the phenotype centric model of the data warehouse is designed as follows (concepts and attributes are capitalized). A taxon or gene may be associated with one or more PHENOTYPE(s) and a PHENOTYPE may be associated with one or more genes or taxa. A PHENOTYPE is associated with exactly one ENTITY and one QUALITY. A QUALITY may be associated with one or more PHENOTYPE(s). Further, a QUALITY is associated with exactly one CHARACTER, which is a QUALITY as well.

For queries for provenance data about taxon to phenotype assertions, we need to find the publication the assertion is extracted from, the specific text from the publication about character and state, as well as the curators' comments about the assertion.

To effectively execute these 'metadata' queries, the provenance data is modeled as an association attribute. For every instance of the association between a TAXON and a PHENOYPE, we capture CHARACTER. STATE, CURATORS, and PUBLICATION. The PUBLICATION entity with all its attributes is linked to the REIF entity, which is the link to the metadata of the TAXON and PHENOTYPE.

This data warehouse can be reduced to the logical schema shown below

Gene
Gene_id {PK} Gene_Uid Gene_Label





Gene_Alias
Gene_id{FK} Alias





Genotype
Genotype_id{PK} Genotype_Uid Genotype_Label





Taxon
Taxon_id {PK} Taxon_Uid Taxon_Label





Taxon_Alias
Taxon_id {FK} Alias





Taxon_Is_A_Taxon
Taxon_id{FK} Taxon_id{FK}





Entity
Entity_Id {PK} Entity_Uid Entity_Label





Entity_Is_A_Entity
Entity_Id {FK} Entity_Id {FK}





Entity_Part_Of_Entity
Entity_Id {FK} Entity_Id {FK}





Quality
Quality_Id {PK} Quality_Uid Quality_Label





Phenotype
Phenotype_Id {PK} Phenotype_Uid Inheres_In_Entity_id {FK} Towards_Entity_id {FK} Is_A_Quality_id {FK} Is_A_Character_id {FK} Has_count





Gene_Genotype_Phenotype
Gene_Id {FK} Genotype_Id {FK} Phenotype_Id {FK}





Taxon_Phenotype
Taxon_Id {FK} Phenotype_Id {FK} Reif_Id {FK}





Taxon_Phenotype_Metadata
Reif_Id {PK} Character_Text State_Text Curators Curator_Comments





Publication
Publication {PK} Primary_Title Secondary_Title Pages Volume Abstract Year





Publication_Reif_id
Publication {FK} Reif_Id {FK}